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多变量MR可以减轻双样本MR中的偏差,使用共变量调整的总结关联

Joe Gilbody1,2, Maria Carolina Borges1,2, George Davey Smith1,2

  • 1MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

Genetic epidemiology
|January 15, 2025
PubMed
概括

多变量孟德尔随机化 (MVMR) 可以纠正基因研究中的偏差,这是由全基因组关联研究 (GWAS) 中的共变量调整引起的. 这种方法可以恢复对结果的无偏的因果效应估计,即使GWAS数据经过调整.

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