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一个STING-CASM-GABARAP通路在 lysosomes 中激活LRRK2

Amanda Bentley-DeSousa1,2,3,4,5, Agnes Roczniak-Ferguson1,2,3,4,5, Shawn M Ferguson1,2,3,4,6,5

  • 1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

The Journal of cell biology
|January 15, 2025
PubMed
概括

研究人员发现了一种控制LRRK2激酶活性的新途径,将 lysosome损伤和STING信号与帕金森病和克罗恩病联系起来. 这一发现揭示了LRRK2调节的关键机制.

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