美国奥姆斯特德县和马丁尼克岛的MOG抗体相关疾病流行病学
Laura Cacciaguerra1,2, Elia Sechi3, Isabelle Komla-Soukha4
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Journal of neurology
|January 15, 2025
概括
这项研究报告了美国和马丁尼克的髓寡基基蛋白抗体相关疾病 (MOGAD) 流行病学. MOGAD影响所有年龄段,具有有利的基于人口的结果,尽管儿童在新病例中占比较高.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 髓寡干细胞糖蛋白抗体相关疾病 (MOGAD) 是一种罕见的自身免疫性疾病,影响中枢神经系统.
- 准确的流行病学数据对于了解疾病负担和资源分配至关重要.
- 之前的研究缺乏关于不同人群中MOGAD发病率和患病率的全面数据.
研究的目的:
- 确定在明尼苏达州奥姆斯特德县 (美国) 和马丁尼克 (法属加勒比海) 的MOGAD的发病率和流行率.
- 应用2023年MOGAD的诊断标准,以确保一致的病例识别.
- 在两个不同的地理区域之间比较MOGAD的流行病学特征.
主要方法:
- 在2003年至2018年期间,在奥姆斯特德县和马丁尼克进行了一项比较流行病学研究.
- 根据年龄和性别调整的发病率和流行率是使用波桑回归计算的.
- 在存档的血清上,使用基于活细胞的测定方法进行了髓寡干细胞糖蛋白免疫球蛋白G (MOG-IgG) 测试.
主要成果:
- 在奥姆斯特德县 (3.70/100,000) 和马丁尼克 (2.61/100,000) 的MOGAD患病率相似.
- 与马丁尼克 (1.18/百万人年) 相比,奥姆斯特德县 (3.00/百万人年) 的发病率更高.
- 在奥姆斯特德县 (29%) 的发生MOGAD病例中,儿童占比高于马丁尼克 (11%) 的发生MOGAD病例,在发生中枢神经系统脱髓化疾病中,MOGAD在儿童中比成年人更为常见 (13-14%对比2-4%). 常见的表现包括视神经炎和脑膜炎. 复发的MOGAD发生在56%的患者中.
结论:
- 这项研究为美国和马丁尼克的MOGAD发病率和流行率提供了第一个基于人口的估计.
- MOGAD影响了广泛的年龄范围,在儿童中具有倾向,但不仅限于儿科患者.
- 对于MOGAD的基于人口的结果似乎是有利的,在随访时,扩展残疾状况量表 (EDSS) 的中位数得分较低.
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