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Updated: Jun 2, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
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Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

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低形态RAG2缺乏促进了自我反应性B细胞的选择

Christopher D Thouvenel1, Christopher M Tipton2, Yasuhiro Yamazaki3

  • 1Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, USA.

Journal of clinical immunology
|January 15, 2025
PubMed
概括

轻微的低形态RAG2突变会导致各种免疫缺陷症状,即使在兄弟姐妹中也是如此. 这项研究揭示了自我反应性B细胞如何扩张而不触发自身免疫,扩大了我们对RAG缺乏症的理解.

关键词:
超强IgMM的情况.低形态的RAG缺乏症边缘区域B的单元格为边缘区域B.在VH4-34中使用.

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