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通过灰色和白质特征网络解释多发性硬化症的认知功能:一个联合独立组件分析

Senne B Lageman^1,2, Amy Jolly¹, Nitin Sahi¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, Faculty of Brain Sciences, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

Journal of neurology

|January 15, 2025

概括

在多发性硬化症 (MS) 中,灰色和白质的联合独立组件分析 (ICA) 对某些领域比单组织ICA更好地解释认知功能. 这种方法揭示了灰质和白质损伤的结合如何影响MS的认知.

科学领域:

神经成像是一种神经成像.
神经学神经学
认知科学认知科学

背景情况:

多发性硬化症 (MS) 的认知障碍 (CI) 并不能完全通过全脑体积来解释.
独立组件分析 (ICA) 确定了与CI相关的区域灰质 (GM) 和白质 (WM) 损伤模式.
转基因和WM病理同时发生,表明模式可能跨越两种组织类型.

研究的目的:

评估GM和WM特征的联合ICA是否比单组织ICA更好地解释MS中的认知功能.
调查组织特异性特征对MS各种认知领域的差异影响.

主要方法:

89名多发性硬化症患者接受了认知测试和磁共振成像 (MRI).
使用结构T1和扩散权重图像来测量GM体积和WM连接体.
ICA分别应用于GM和WM,并联合使用,为每个方法提取20个组件.

主要成果:

联合-ICA组件与所有认知领域有显著关联.
联合ICA解释了执行功能 (R2=0.35) 和视觉记忆 (R2=0.30) 中的最大差异.
WM-ICA显示工作记忆的最大变异 (R2=0.23);处理速度或口头记忆没有显著差异.

结论:

在解释MS中的某些认知领域方面,GM和WM的联合ICA优于单组织ICA.
在MS中,认知领域受到组织特异性特征的差异性影响.
考虑跨越GM和WM的过程对于理解MS相关的认知障碍至关重要.

关键词:

认知认知是一种认知.灰色的物质就是灰色的物质.联合独立组件分析分析多发性硬化症是多发性硬化症.白质是白质的组成部分.

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