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胺基核酸间结合抑制了短干扰RNA的微RNA类非目标活性

Chandan Pal1, Michael Richter1, Jayamini Harasgama1

  • 1Department of Chemistry, Binghamton University, the State University of New York, Binghamton, New York 13902, United States.

ACS chemical biology
|January 15, 2025
PubMed
概括

化学修饰增强了短干扰RNA (siRNA) 疗法. 氨基酸结合,特别是在3位,显著减少了非目标效应,改善了siRNA的特异性和治疗潜力.

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