复发模式和 Pleurectomy 后的管理 pleural mesothelioma 的皮下脱皮
Juuso Paajanen1,2, William G Richards1, Yue Xie3
1The Thoracic Surgery Oncology laboratory and the International Mesothelioma Program (www.impmeso.org), Division of Thoracic Surgery and the Lung Center, Brigham, and Women's Hospital, and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Annals of surgery
|January 15, 2025
概括
肺切除术后肺间皮质瘤的复发主要是局部的. 重复手术可以为某些患有复发性疾病的患者提供良好的局部控制.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 恶性多层甲状腺瘤研究研究
背景情况:
- 瘤复发显著影响了在为肺部间皮瘤 (PM) 进行手术治疗后的长期存活率.
- 了解复发模式对于改善瘤切除术后患者的治疗结果至关重要.
研究的目的:
- 调查PM患者在PD后瘤复发的主要部位.
- 确定与无病区间 (DFI) 和复发后存活率 (PRS) 相关的因素.
主要方法:
- 在1998年至2022年期间接受PD的436名扩散PM患者的回顾性分析.
- 对术后扫描进行审查,以确定最初瘤复发的时间和位置.
- 多变量分析以确定DFI和PRS的预测因素.
主要成果:
- 局部复发是最常见的模式,在85%的病例中观察到 (N=370).
- 与其他亚型相比,肉类瘤的复发较早,远程传播更频繁.
- 与DFI相关的因素包括年龄,瘤体积,组织学,手术内化疗和TNM阶段. PRS受年龄,表现状况,组织学,化疗,TNM阶段,手术类型和复发次数的影响.
结论:
- 在PD后,多性间皮瘤经常在局部复发.
- 重复手术切除是一种可行的选择,可以在选择的患有复发性PM的患者中实现局部控制.
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