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缺乏TLR9会加剧系统性Cryptococcus gattii感染期间的眼睛损伤和视力损失

Elias Barbosa da Silva-Junior¹, Victor Guedes de Araujo¹, Carlla Assis Araujo-Silva¹

¹Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.

The Journal of infectious diseases

|January 15, 2025

概括

收费类受体9 (TLR9) 缺陷在小鼠中加剧了眼球密码球菌病. 缺乏TLR9会导致真菌负担增加和由于视网膜损伤和视神经炎症而逐渐失明.

科学领域:

免疫学免疫学免疫学
菌类学菌类学是指菌类学.
眼科医生眼科眼科

背景情况:

加密球菌 (Cryptococcus gattii) 是一种环境真菌,会引起系统性感染,包括眼球的加密球菌,这可能导致失明.
眼部密码球菌病通常与中枢神经系统 (CNS) 的参与有关.
收费类受体9 (TLR9) 在控制诸如加密球菌病之类的真菌感染方面发挥着作用.

研究的目的:

研究TLR9信号在系统性Cryptococcus gattii感染的眼睛表现中的作用.
在小鼠模型中评估TLR9缺乏对真菌负担和眼睛病理的影响.

主要方法:

使用了缺乏托尔类受体9 (TLR9-/-) 的C57BL/6小鼠.
系统感染的小鼠感染了Cryptococcus gattii.
评估眼睛损伤,视网膜,玻璃体和视神经的真菌负担,以及感染后三周的本病学变化.

主要成果:

TLR9-/-小鼠表现出明显的眼睛损伤和视网膜,玻璃体和视神经的高真菌负担.
在TLR9-/-小鼠中观察到囊多糖糖糖甘 (GXM) 的沉积,星光病变和视网膜形态变化.
这些病理变化导致在没有TLR9信号的情况下逐渐失明.

结论:

在系统性Cryptococcus gattii感染期间,TLR9信号传递对于控制眼睛参与至关重要.
缺少TLR9导致对眼部病理和失明的敏感性增加.
用激动剂向TLR9可能是眼球密码球菌病的潜在治疗策略.

关键词:

克里普托科克斯 (Cryptococcus gattii) 是一个有毒的菌种.细胞微生物学细胞微生物学组织病理学分析.眼内感染眼内感染微生物病原体微生物病原体眼睛的损伤眼睛的损伤在R265中,使用R265.类似收费的接收器9

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