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在患有1型糖尿病的青少年中,90天时间范围的变化启动了不同的自动化胰岛素输送系统
Sonia Gera1, Andrew Rearson1, Greyson Baker1
1Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
The Journal of clinical endocrinology and metabolism
|January 15, 2025
概括
这项研究发现,使用Insulet Omnipod 5 (OP5) 或Tandem Control IQ (CIQ) 自动化胰岛素输送 (AID) 系统的1型糖尿病 (T1D) 青少年的90天时间范围没有显著差异. 患者的偏好应指导AID系统的选择.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 儿童糖尿病管理管理
背景情况:
- 自动化胰岛素输送 (AID) 系统正在改变青少年1型糖尿病 (T1D) 管理.
- 岛屿Omnipod 5 (OP5) 和Tandem Control IQ (CIQ) 是这个人口在美国使用的最常见的AID系统.
- 在儿科人群中,这些领先的AID系统之间对血糖结果的比较数据有限.
研究的目的:
- 进行首次对T1D发病的青少年血糖结局的头对头比较,并启动OP5或CIQ AID系统.
- 分析关键血糖指标的变化,特别是时间范围 (TIR),在启动这两个常见的AID系统后.
主要方法:
- 一项回顾性,单中心研究包括428名患有T1D的青少年 (<21岁),他们在2020年1月至2023年12月期间启动了OP5或CIQ.
- 参与者需要至少70%的持续血糖监测 (CGM) 活跃时间.
- 评估了90天TIR变化,使用多重线性回归,调整相关的共变量,并根据基线TIR类别进行了分分析.
主要成果:
- 在OP5和CIQ两组中,90天TIR显著改善 (p<0.001).
- OP5用户的TIR增加了11.8%,而CIQ用户的TIR增加了9.8%,两种系统之间没有统计学上显著的差异 (p=0.08).
- 根据两个AID系统之间的基线TIR类别,没有观察到90天TIR的显著差异.
结论:
- 启动OP5或CIQ自动化胰岛素输送系统导致1型糖尿病青少年的90天时间范围中可比且临床上无意义的差异.
- 在为儿科T1D管理选择AID系统时,应优先考虑患者的偏好和患者,家庭和医疗保健提供者之间的共同决策.
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