在患有晚期软组织肉瘤的患者中,使用托洛福斯法米德进行维护治疗 - - 追溯单中心分析
Anton Burkhard-Meier1, Vera Valerie Rechenauer2, Luc M Berclaz3
1Comprehensive Cancer Center Munich and Department of Medicine III, University Hospital, LMU Munich, Munich, Germany ; Bavarian Cancer Research Center (BZKF), Munich, Germany. anton.burkhardmeier@med.uni-muenchen.de.
Acta oncologica (Stockholm, Sweden)
|January 15, 2025
概括
使用托洛胺 (TRO) 的口服维持疗法对晚期软组织肉瘤 (STS) 患者显示出有前途. 在TRO维持之前没有疾病证据 (NED) 显著改善了结果,特别是在转移病例中.
科学领域:
- 在瘤学瘤学.
- 医学瘤学 医学瘤学
- 肉瘤研究研究 肉瘤研究
背景情况:
- 先进的软组织肉瘤 (STS) 的预后不好.
- 托洛福斯法米德 (TRO) 是一种潜在的口服维持疗法选择.
- 这项研究评估了TRO维护在高级STS中的有效性.
研究的目的:
- 为了确定 trofosfamide (TRO) 维持治疗的临床价值和结果.
- 确定可能从TRO维护中受益最多的患者子组.
- 分析影响TRO治疗晚期STS患者生存的预后因素.
主要方法:
- 对59名接受TRO维护治疗的晚期STS患者 (2016-2022) 的回顾性分析.
- 评估临床参数,包括组织学,转移状态和先前的治疗.
- 生存分析 (无事件生存[EFS]和总生存[OS]) 和多变量分析.
主要成果:
- 中位数EFS为9.5个月,中位数OS为33.2个月.
- 在TRO维持之前没有疾病证据 (NED) 的患者显著延长了EFS (p=0.024).
- 与G3相比,G2组织学与较长的生存期相关 (p=0.030).
结论:
- 托洛福斯法米德 (TRO) 维持疗法似乎可以改善晚期STS患者的结果.
- 在TRO维持之前实现NED的转移性STS患者显示出特别有利的结果.
- 对TRO作为STS的维持疗法的进一步研究是有必要的.
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