鼻子微生物群预测甲基西林耐药性葡萄球菌在重症儿童的殖民化
Kathleen Zani1, Joseph Hobeika2, Yilun Sun3
1Department of Pediatrics, Division of Critical Care, University of Tennessee Health Science Center, Memphis, TN, United States of America.
PloS one
|January 15, 2025
概括
特定的鼻腔细菌可以预测儿科重症监护病房中耐甲素的葡萄球菌殖民. 这一发现可以改善对这些耐药感染的早期检测和预防策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 儿科重症监护 儿科重症监护
背景情况:
- 目前在儿科重症监护病房 (PICU) 进行的抗甲素黄金葡萄球菌 (MRSA) 监测有限,资源密集.
- 它无法检测出其他抗甲基西林的葡萄球菌物种,因此需要改进检测方法.
研究的目的:
- 为了确定在PICU入院时,耐甲素的葡萄球菌殖民的流行率.
- 为了确定甲基西林耐药性葡萄球菌殖民的鼻腔微生物组预测因素.
主要方法:
- 在20个床位的PICU (2020-2021) 中进行前性队列研究.
- 在PICU入院后五天内,收集MRSA培养,鼻微生物组分析和mecA+qPCR的前鼻拭子.
- 计算的预测值,用于甲素耐药的葡萄球菌携带和鼻腔微生物组属性.
主要成果:
- 在62名患者中,5名 (8.0%) 患有MRSA阳性鼻培养.
- 在63名患者中,有22名 (35.5%) 携带了耐美西林葡萄球菌 (MRSA或耐美西林凝结酶阴性葡萄球菌).
- 在PICU期间发烧与MRSA或MRCoNS携带有关. 特定的微生物 (血球菌,链球菌,Prevotella,Corynebacterium) 预测了对甲基西林耐药的葡萄球菌殖民.
结论:
- 携带耐美西林的葡萄球菌会在重症儿童中造成传染风险.
- 截然不同的鼻腔微生物群落似乎有助于对甲基西林耐药的葡萄球菌的殖民.
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