一个分布式的皮质下电路,与工具搜索有关威胁的信息相关联
Hailey A Trier1, Nima Khalighinejad1, Sorcha Hamilton1
1Wellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford OX1 3TA, United Kingdom.
概括
人类自发地在寻求奖励和监控威胁之间切换. 哈本,背脊核 (DRN) 和其他区域的大脑活动跟踪威胁水平并驱动这种切换行为.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 行为生物学 行为生物学
背景情况:
- 日常活动需要在威胁检测和寻求奖励的行为之间交替进行.
- 了解这些行为开关背后的神经机制对于理解适应性反应至关重要.
研究的目的:
- 为了研究与威胁和奖励导向行为之间自发切换相关的神经活动.
- 探索威胁和奖励概率估计如何影响这些行为转变.
- 识别特定的大脑区域和活动模式,参与威胁监测和信息搜索.
主要方法:
- 在健康的人类参与者中利用7T功能磁共振成像 (fMRI).
- 采用一种自然主义的任务,旨在引起在食和威胁警之间自发的切换.
- 分析神经活动模式与估计的威胁和奖励概率相关.
主要成果:
- 切换行为是由感知到的威胁和奖励可能性调节的.
- 追踪威胁和采取警状态涉及分布式大脑活动,包括大脑,背脊核 (DRN),前带皮质和前带岛.
- 在威胁监测,信息搜索,威胁检测和回到以奖励为导向的行为过程中观察到不同的神经模式.
- 个人在DRN活动中的差异与寻求威胁信息的程度相关.
结论:
- 哈本,DRN和相关电路在调节威胁和奖励行为之间的开关方面发挥着关键作用.
- 这个电路中的神经活动模式区分监控威胁,寻找威胁信息和检测威胁.
- 个人DRN功能的变化与与威胁相关的信息搜索行为的差异有关.
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