在50至60岁的女性中,使用罕见的佐勒德龙酸预防骨折
Mark J Bolland1, Zaynah Nisa1, Anna Mellar1
1From the Department of Medicine, University of Auckland, Auckland, New Zealand (M.J.B., Z.N., A.M., C.G., V.P., B.M., A.G., I.R.R., G.G., A.H.); the Department of Psychology, Stanford University, Stanford, CA (C.G.); and the Department of Radiology, Starship Hospital, Auckland, New Zealand (S.B.).
The New England journal of medicine
|January 15, 2025
概括
不频繁的佐莱德罗纳特治疗有效地预防了早期绝经后妇女的脊椎骨折. 一项为期10年的试验显示,与安慰剂相比,在基线和5年内给予佐莱德罗纳特显著降低骨折风险.
科学领域:
- 骨质疏松症的研究研究.
- 药理干预措施 药理干预
- 绝经后妇女的骨健康状况
背景情况:
- 已知佐莱德罗纳特可以预防老年妇女的骨折,不经常服用.
- 它对骨密度和骨周转的长期影响表明,它可能有助于延长骨折的预防.
- 不常见的zoledronate在早期绝经后妇女预防脊椎骨折的疗效仍未得到研究.
研究的目的:
- 为了评估不频繁的佐莱德龙酸剂在预防脊椎骨折方面的有效性.
- 评估佐莱德酸盐对早期绝经后妇女骨健康的长期影响.
- 为了在10年内比较治疗群体和安慰剂组之间的骨折发生率.
主要方法:
- 一个10年的前性,双盲,随机,安慰剂对照试验.
- 涉及早期绝经后的女性 (50-60岁) 患有骨质疏松症 (T-分数 -2.5至 -1).
- 这些组在基线和5年内接受佐列德罗纳特 (5毫克),在基线和5年后接受佐列德罗纳特/安慰剂,或在两个时间点接受安慰剂. 主要终点:形态度的脊椎骨折.
主要成果:
- 共有1054名妇女被录取;1003人完成了10年.
- 形态度的脊椎骨折发生在6.3%的 (zoledronate-zoledronate) 和6.6%的 (zoledronate-安慰剂) 患者中,与安慰剂组的11.1%相比 (P=0.04对于zoledronate-zoledronate).
- 与安慰剂相比,佐莱德罗纳特显著降低了骨质疏松性骨折,任何骨折和重大骨折的风险.
结论:
- 在基线和5年后给予佐莱德罗纳特有效地预防了早期绝经后妇女的形态学脊椎骨折.
- 这项研究表明,在这个人口群体中,不频繁的佐勒德龙酸治疗对于骨折预防的长期疗效.
- 研究结果支持不频繁使用索莱德酸盐作为早期绝经后妇女骨质疏松症管理的可行策略.
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