神经退行研究的微流体和计算工具

Kin Gomez1, Victoria R Yarmey1,2, Hrishikesh Mane1

  • 11Department of Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA;

概括

微流体技术和先进的计算工具通过增强生物标志物分析和数据解释来加速神经退行性疾病 (ND) 研究,以更好地诊断和治疗.

相关概念视频

Eulerian and Lagrangian Flow Descriptions01:22

Eulerian and Lagrangian Flow Descriptions

Fluid flow analysis is critical in many scientific and engineering disciplines, and two principal approaches are used to describe this flow: the Eulerian and Lagrangian methods. These methods offer different perspectives on monitoring and analyzing the motion of fluids, each with distinct advantages depending on the scenario.
The Eulerian method focuses on fixed points in space where fluid properties, such as velocity, pressure, and temperature, are observed as the fluid moves between these...
Reynolds Transport Theorem01:24

Reynolds Transport Theorem

The Reynolds transport theorem provides a framework to relate the time rate of change of an extensive property within a system to that in a control volume, which is crucial for analyzing fluid dynamics. Extensive properties, such as mass, velocity, acceleration, temperature, and momentum, can be expressed in terms of the mass of a fluid portion. These properties are called extensive because they depend on the system's size, while intensive properties are their corresponding values per unit mass.
Plane Potential Flows01:23

Plane Potential Flows

Plane potential flows simplify fluid motion by assuming the fluid to be irrotational and incompressible. These characteristics allow these flows to be described by a velocity potential function, ϕ, representing the flow speed in a given direction, and a stream function, ψ, that visualizes the flow path, both governed by Laplace's equation. These parameters help in estimating flow patterns, velocity distributions, and pressure fields around various hydraulic structures.
Uniform Flow
Uniform flow...
Navier–Stokes Equations01:28

Navier–Stokes Equations

For incompressible Newtonian fluids, where density remains constant, stresses show a linear relationship with the deformation rate, defined by normal and shear stresses. Normal stresses depend on the pressure exerted on the fluid and the rate of deformation in specific directions, which determines how fluid flows under varying pressures. Shear stresses, on the other hand, act tangentially across fluid layers. They explain how adjacent fluid layers slide relative to one another, connecting...
Couette Flow01:22

Couette Flow

Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
Typical Model Studies01:30

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.