增强的压电传感器可以区分实时心律失常,用于预测心力衰竭
Tao Jing1, Yaolei Zhang2, Zhongtao Li3
1Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, Sichuan, PR China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China.
增强的聚乙烯化物 (PVDF) 传感器与CoFe2O4合剂和对齐的纤维显示出改善的压电性,用于敏感的心律监测. 这种非侵入性方法可提供早期检测心力衰竭变异.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 心脏病学 心脏病学
背景情况:
- 监测心律对于诊断心力衰竭至关重要.
- 标准的聚乙烯化物 (PVDF) 传感器由于有限的压电性而缺乏灵敏度.
- 需要增强的压电传感器来准确监测心脏.
研究的目的:
- 为了增强PVDF传感器的压电特性.
- 开发高灵敏度的压电传感器,用于心律监测.
- 用这些传感器评估早期心力衰竭检测的潜力.
主要方法:
- 用CoFe2O4合PVDF和调整纤维以提高压电性.
- 使用里叶变换红外光谱 (FTIR) 和第一原理模拟来确认PVDF相变.
- 测试传感器的灵敏度,频率特征,响应时间,稳定性,透性和自我清洁能力.
主要成果:
- 通过兴奋剂和对齐,实现了β-PVDF含量显著增加 (从51.54%到82.36%).
- 开发了对齐的PVDF/CoFe2O4传感器,其灵敏度为17.28mV kPa−1,明显高于随机PVDF/CoFe2O4 (13.40mV kPa−1) 和PVDF (2.16mV kPa−1) 传感器.
- 演示了传感器在心力衰竭老鼠模型中区分心律变化的能力.
结论:
- 对齐的PVDF/CoFe2O4传感器表现出优越的压电特性和心脏监测的灵敏度.
- 增强的传感器可以检测振幅和周期变化,这表明心力衰竭正在演变.
- 这种非侵入性方法对早期心力衰竭的预测和预防有希望.
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