改造瘤微环境通过多功能纳米平台编排的机械疗法与化疗免疫疗法以协同增强抗癌效率
Wenqiang Chen1, Zhe Zhang2, Yunfei Han1
1School of Pharmacy, Shandong Second Medical University, Weifang, 261053, China.
Biomaterials
|January 15, 2025
概括
这项研究开发了新的纳米粒子,将机械疗法与化疗免疫疗法结合起来,以克服固体瘤障碍. 这些纳米粒子有效地降低了瘤机械障碍,并重塑了免疫抑制瘤微环境,提高了癌症治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 固体瘤存在机械障碍和免疫抑制瘤微环境 (TME),阻碍纳米医药的透和治疗结果.
- 目前的治疗方法在克服瘤部位中的这些物理和生物障碍时面临着挑战.
研究的目的:
- 开发一个多功能纳米平台,将机械疗法与化疗免疫疗法结合起来,同时解决瘤物理障碍和免疫抑制TME.
- 提高纳米医药的透率,提高癌症治疗的整体疗效.
主要方法:
- 在甲 (DMS) 和cis-aconityl-doxorubicin (CAD) 的同时封装成酸功能化聚乙烯胺 (PEI-PBA) 载体.
- 在现场用化物修饰的聚乙烯糖醇 (PEG) 进行屏蔽,以形成CAD/DMS@PEG/PEI-PBA (CD@PB) 纳米粒子 (NP).
- 评估NP多功能性,包括体内循环,TME反应药物释放和协同治疗效应.
主要成果:
- 通过对TME敏感的PEG脱,CD@PBNP体现了长期的体内循环和有效的细胞吸收.
- 酸性TME和内体pH触发了药物释放和内体逃逸到细胞质中.
- 德克萨米他 (DMS) 有效地降低了树皮密度,削弱了机械屏障,并促进了多克索鲁比 (DOX) 的核进入.
- DOX诱导免疫细胞死亡 (ICD),激活化疗免疫治疗的抗瘤免疫力.
- 在4T1小鼠乳腺癌模型中表现出卓越的抗瘤疗效,重塑TME并与化疗免疫疗法协同机制治疗.
结论:
- 开发的CD@PBNP通过克服物理和生物障碍,为癌症治疗提供了多维的方法.
- 这一策略有效地协调了机械疗法与化疗免疫疗法,导致抗瘤效率的协同增强.
- 该研究提出了一个有希望的范式,通过综合纳米医学方法克服固体瘤治疗的挑战.
相关概念视频
Tumor Immunotherapy
469
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
469
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Cancer Vaccines
336
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
336


