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在子宫内暴露于寨卡病毒的早期和长期不良结果

Fabio Antonio Venancio^1,2, Maria Eulina Quilião³, Sanny Cerqueira de Oliveira Gabeira⁴

¹Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

|January 15, 2025

概括

怀孕期间感染寨卡病毒 (ZIKV) 会增加儿童出现不良结果的风险,包括神经发育迟缓. 早期怀孕中ZIKV暴露显著提高了这些长期健康问题的几率.

科学领域:

* 神经科学是一门神经科学.
* 传染病传染病
* 儿科儿童医学

背景情况:

*怀孕期间感染寨卡病毒 (ZIKV) 与先天性寨卡综合征 (CZS) 和儿童潜在的神经发育问题有关.
*了解ZIKV对儿童发育的影响对于公共卫生干预至关重要.

研究的目的:

* 评估怀孕期间的寨卡病毒 (ZIKV) 感染是儿童早期和长期不良结果的风险因素.
* 评估母体ZIKV感染与神经发育变化之间的关联.

主要方法:

* 一项回顾性-前性,匹配的队列研究,涉及巴西马托格罗索杜苏尔州 (2018-2022) 的母婴对.
*从巴西健康监测系统收集的数据,评估儿童是否有先天性异常和神经发育迟缓.
*使用发病风险比率 (IRR) 和原始赔率比率 (OR) 来确定风险关联的统计分析.

主要成果:

*在子宫内暴露于ZIKV的儿童与未暴露的儿童相比,不良后果的风险几乎高出3倍.
*在暴露于ZIKV的儿童中,观察到明显更高的运动 (IRR,3.4) 和认知延迟 (IRR,4.7) 的风险.
*与第三个三个月的感染相比,母亲在头三个月的感染与孩子的不良结果的几率增加了11.2倍.

结论:

*在子宫内暴露于ZIKV会在幼儿时代引起神经发育延迟的重大风险,即使没有CZS.
* 怀孕期间母亲感染ZIKV的时间是儿童不良结果的关键预测因素.

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