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Updated: Jun 2, 2025

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

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U2AF1突变会导致血液细胞和白血病细胞的氧化应激和DNA修复缺陷

Yishuang Li1, Xuanjia Dong1, Haiyan Xing1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Cell Therapy for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300030, China; Tianjin Institutes of Health Science, Tianjin, 301617, China.

Free radical biology & medicine
|January 15, 2025
PubMed
概括

结合体组分U2AF1的突变会增加活性氧物种 (ROS) 和DNA损伤. 这种U2AF1突变有助于骨髓质疏松/骨髓扩散性瘤 (MDS/MPN) 和急性骨髓性白血病 (AML) 的不良预后.

关键词:
DNA损伤的积累,造血细胞的细胞积累.DNA修复反应的反应反应.氧化应激是一种氧化应激.这种突变是U2AF1突变.

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