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开发一种抗微生物组织修复剂,使用四级甲基基 (K18):一个体外研究

Vrinda Gupta¹, Kyumin Whang¹

¹Department of Comprehensive Dentistry, UT Health San Antonio, San Antonio, USA.

Journal of prosthodontic research

|January 15, 2025

概括

将K18四级甲基基 (QAS) 添加到组织修复剂中,增强了对常见口腔微生物的抗菌特性. 保持了流量和硬度等材料特性,尽管水吸附和质量损失增加.

科学领域:

牙科材料科学牙科材料科学
生物材料工程生物材料工程
微生物学微生物学

背景情况:

组织调节剂对于假牙佩戴者至关重要,但易受微生物殖民的影响.
开发这些材料中的抗菌性质对于口腔健康至关重要.
四次性化合物 (QAC) 已知其抗微生物疗效.

研究的目的:

评估K18四级甲基基 (QAS) 对组织修复剂的物理,机械和抗菌性能的影响.
评估K18-QAS在商业组织修复剂基础上的材料兼容性和有效性.

主要方法:

将K18-QAS纳入甲基甲酸盐 (K18-MMA) 中的0%,15%和20% (w/w) 在商业组织修复剂中.
评估材料特性,包括Shore A硬度,接触角度,流量,液体吸附和质量损失.
使用标准微生物测试对 Streptococcus mutans,Streptococcus sanguinis 和 Candida albicans 的抗菌活性进行评估.

主要成果:

增加了Shore A硬度,具有更高的K18-MMA度;接触角度没有显著变化.
组织调节剂的流量保持在ISO规格范围内,尽管度依赖的减少.
对S. mutans,S. sanguinis和C. albicans的显著抗菌活性观察到15%和20%的K18-MMA度.
在含有K18-MMA的调节剂中,注意到液体吸附和质量损失的增加,特别是在4周后.

结论:

K18-MMA有效地赋予组织修复剂对关键口腔微生物的抗菌特性.
添加K18-MMA并没有对流量,硬度和水友性等关键材料特性产生负面影响.
虽然K18-MMA增强了抗菌功能,但临床医生应该考虑随着时间的推移增加水吸附和质量损失的可能性.

关键词:

牙口腔炎是一种牙口腔炎.四次性化合物四次性化合物四次性氨基甲基基基氨基.软层材料是一种软层材料.组织调节剂组织调节剂

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