临床特征和高症的危险因素在一个中国队列与轴性脊柱关节炎:一个多中心的回顾性研究
Yuening Chen1, Zhaoyang Geng2, Yu Wang3
1Y. Chen, MD, H. Liu, MD, Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
The Journal of rheumatology
|January 15, 2025
概括
轴性脊柱关节炎 (axSpA) 的超症与男性性别,更长的疾病持续时间和更高的炎症有关. 有效的药理治疗可以改善结果,并延迟脊髓进展.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 临床流行病学临床流行病学
背景情况:
- 超症是轴性脊柱关节炎 (axSpA) 的常见并发症.
- 了解其风险因素对于管理疾病进展和患者结果至关重要.
研究的目的:
- 在中国 axSpA 队列中调查临床特征并确定过症的危险因素.
- 开发 axSpA 患者过症的预测模型.
主要方法:
- 一项涉及11个中心607名axSpA患者的横截面研究.
- 进行了单变量和多变量逻辑回归分析.
- 为临床评估和影响因子可视化而开发了一个名图模型.
主要成果:
- 男性的性别,疾病持续时间,患者的整体评估,红细胞沉积率,mSASSS,药物治疗和ASDAS-CRP是高症的重要危险因素.
- 开发的诺莫格拉姆模型显示出高预测精度 (AUC=0.98,精度=0.95).
- 在ASAS HI和mSASSS之间存在正相关性;在药理治疗和疾病活性/mSASSS之间存在负相关性.
结论:
- 控制疾病活动对于管理 axSpA 相关的高密度症至关重要.
- 建议采取积极的药理治疗,以减轻放射性进展,并增强患者报告的结果.
- 建议改变生活方式,如戒烟和控制体重,以减少残疾.
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