肝硬化和并发症肝细胞癌 - 扩大免疫治疗的指示
1Brussels Health Campus, Department of Gastroenterology and Hepatology, University Hospital Brussels (UZ Brussel), Brussels, Belgium.
Acta clinica Belgica
|January 15, 2025
概括
免疫检查点抑制剂现在是高级肝癌 (HCC) 的标准. 研究正在将免疫疗法扩展到早期阶段,并作为肝移植的辅助,改善患者的治疗结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 肝细胞癌 (HCC) 发病率正在增加,代谢功能障碍相关的脂肪性肝病是西方国家的主要驱动因素.
- 治疗的进步提供了更多的选择,强调了多学科护理对改善患者结果的重要性.
研究的目的:
- 审查目前和正在进行的免疫检查点抑制剂 (ICI) 基疗法的临床试验,用于HCC的各个阶段.
- 讨论免疫疗法在HCC管理中的不断扩大的作用,包括早期阶段和作为肝移植的辅助.
主要方法:
- 对已发表的临床试验和正在进行的针对HCC基于ICI治疗的研究进行审查.
- 对晚期,中期和早期HCC的治疗策略的分析.
- 评估免疫疗法在肝移植中降低HCC的作用.
主要成果:
- 基于免疫检查点抑制剂的治疗是高级HCC的标准一线治疗.
- 在中期HCC中,报告了将免疫疗法与局域疗法结合治疗的积极结果.
- 新出现的证据支持免疫治疗对降低HCC的安全性和有效性,以促进肝移植.
结论:
- 基于ICI的疗法在不同疾病阶段的HCC治疗中取得了重大进展.
- 免疫治疗的应用正在扩大,为早期疾病患者和等待肝移植的患者提供了新的希望.
- 多学科决策对于优化新型免疫治疗剂在HCC管理中的使用至关重要.
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