长期暴露于环境空气污染和儿童的表观遗传年龄加速
Wenli Ni1,2, Anne K Bozack3, Sheryl L Rifas-Shiman4
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
American journal of epidemiology
|January 15, 2025
概括
暴露于细颗粒物 (PM2.5) 空气污染可能会减缓儿童的表观遗传衰老. 这项研究发现PM2.5和下霍尔瓦特之间存在关联.
科学领域:
- 环境表观遗传学环境表观遗传学
- 儿科 环境卫生 儿童 环境卫生
- 公共卫生 公共卫生
背景情况:
- 环境空气污染与成人表观遗传衰老加速 (EAA) 有关.
- 空气污染对儿童EAA的影响尚不清楚.
- 表观遗传钟测量生物衰老,提供对健康和疾病的洞察力.
研究的目的:
- 调查空气污染暴露与儿童EAA之间的关联.
- 分析不同类型的EAA (HorvathEAA,IEAA,Skin&BloodEAA) 与空气污染物相关的情况.
主要方法:
- 分析了Project Viva队列中的457名儿童的数据.
- 从白细胞计算EAA,使用Horvath的,内在的和皮肤和血液的表观遗传钟.
- 使用通用添加模型来评估空气污染物 (PM2.5,NO2,O3) 和EAA.之间的关联.
主要成果:
- 在儿童中,较高的365天平均PM2.5暴露与较低的HorvathEAA相关 (-0.26年/IQR).
- 对IEAA和Skin&BloodEAA也观察到类似的趋势,尽管经过调整后,这些趋势在统计学上并不显著.
- 对于终身PM2.5,NO2,O3或接近道路的情况,没有发现显著的关联.
结论:
- 之前的365天平均PM2.5暴露可能与儿童的HorvathEAA减少有关.
- 需要进一步的研究来证实这些发现,并了解潜在的机制.
- 这项研究强调了空气质量对儿童发育和衰老的潜在影响.
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