血清高密度脂蛋白胆固醇与维生素D缺乏人群中的骨矿物质密度之间的相关性
Miaomiao An1, Chunyan Wu2, Shaohui Feng2
1The Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, Guizhou, China.
Journal of bone and mineral metabolism
|January 15, 2025
概括
高密度脂蛋白 (HDL) 胆固醇与40岁以上维生素D缺乏的成年人骨矿物质密度 (BMD) 相反相关. 在这个人群中,HDL-C水平≥1.215 mmol/L预测骨质疏松症风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 骨健康 骨健康 骨健康
背景情况:
- 维生素D缺乏症在中年和老年人中普遍存在.
- 血清高密度脂蛋白 (HDL) 胆固醇与骨矿物质密度 (BMD) 之间的关系需要进一步研究,特别是在维生素D缺乏的人群中.
研究的目的:
- 为了检查血清HDL胆固醇和40岁及以上的成年人体内BMD之间的关联.
- 确定维生素D缺乏个体骨质疏松症的潜在预测因素.
主要方法:
- 在2583名40岁以上的成年人接受健康检查的横截面研究.
- 用皮尔森相关性和多重线性回归分析来确定相关性.
- 接收器操作特征 (ROC) 曲线分析确定了对骨质疏松症预测的HDL-C切断水平.
主要成果:
- 该研究发现骨质疏松症的患病率为11.4%,维生素D缺乏症的患病率为78.2%.
- 在维生素D缺乏的个体中,HDL胆固醇与腰椎和股骨部的BMD呈负相关性.
- HDL-C水平≥1.215 mmol/L被确定为骨质疏松症的独立预测因素 (AUC=0.625).
结论:
- 在40岁及以上的维生素D缺乏的成年人中,血清HDL-C与腰椎和大腿部部的BMD相反相关.
- 血清HDL-C度≥1.215 mmol/L是该人口群体中骨质疏松症发生的重要预测因素.
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