毛囊大小类别对触发日卵细胞质量的影响 接受质阶段刺激协议
Xiaoping Liu1,2,3, Weie Zhao1,2,3, Panyu Chen1,2,3
1Reproductive Medicine Research Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, No. 17 Shou-gou-ling Rd., Tianhe District, Guangzhou, 510000, China.
Archives of gynecology and obstetrics
|January 15, 2025
概括
使用较大的卵泡触发质阶段刺激 (LPS) 可以改善卵细胞质量和受精率. 然而,患者年龄是个性化IVF协议调整的关键因素.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 状期刺激 (LPS) 是一种替代性IVF协议.
- 优化触发日条件对于成功的结果至关重要.
- 触发日的毛囊大小可能会影响卵细胞和胚胎质量.
研究的目的:
- 在LPS协议中,评估在触发日变化的主导卵泡大小的影响.
- 为了确定卵泡大小是否影响卵细胞成熟,受精和胚胎发育率.
- 为基于卵泡动态的个性化IVF协议调整提供证据.
主要方法:
- 对661名接受LPS协议的患者 (2015-2023) 的回顾性分析.
- 患者被分为"大","中",和"小"的主导毛囊大小组在人胆激素 (hCG) 触发日.
- 用通用线性模型 (GLM) 分析比较第二阶段 (MII) 卵子细胞率,不成熟卵子细胞率,两个前核 (2PN) 受精率和可用的胚胎率.
主要成果:
- 与"小"组相比",大"毛囊组表现出明显较低的不成熟卵细胞率和较高的2PN受精率 (p=0.005).
- 两组之间没有观察到MII卵细胞率或可用胚胎率的显著差异.
- GLM分析证实毛囊大小影响不成熟卵细胞率和2PN受精率,年龄是改变因素,特别影响老年女性的2PN率.
结论:
- 触发更高比例的大卵泡的LPS与改善卵细胞质量和受精潜力有关.
- 患者年龄是一个显著的共同变量,影响了卵泡大小和受精结果之间的关系.
- 在LPS协议中,个性化调整触发时间应考虑卵泡大小分布和患者年龄,以获得最佳的IVF成功.
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