在临床前研究中,前带皮层的深度大脑刺激减少了阿片类药物成
Mahdi Fatemizadeh1, Esmail Riahi2, Gholamreza Hassanzadeh1
1Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, No. 38, Italia Ave., Ghods St, Keshavarz Boulevard, Tehran, Iran.
Scientific reports
|January 15, 2025
概括
在前带皮质 (ACC) 中进行深度大脑刺激 (DBS) 有效地降低了吗啡奖励和复发. 这种依赖强度的治疗也改善了摩尔因使用障碍的老鼠模型中的认知和运动功能.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 成研究 研究成研究
背景情况:
- 药物使用障碍 (SUD) 是一种慢性复发性疾病.
- 前带带皮质 (ACC) 在各种SUD中发挥作用.
- 吗啡使用障碍仍然是一个重大的公共卫生问题.
研究的目的:
- 为了研究深度大脑刺激 (DBS) 在ACC治疗吗啡使用障碍的有效性.
- 评估ACC DBS对吗啡条件下的地方偏好 (CPP) 获取,灭绝和恢复的影响.
- 评估ACC DBS对与吗啡使用相关的神经活动和行为结果的影响.
主要方法:
- 在甲基中,大鼠在吗啡CPP获取和灭绝阶段接受了高频DBS.
- 评估了吗啡CPP,新型物体识别 (NOR) 和运动运动活动.
- 在核 (NAc) 和前额皮层 (PFC) 中测量了c-Fos蛋白表达.
主要成果:
- 高频ACC DBS (130 Hz,150-200 μA) 在获得过程中抑制了吗啡的奖励作用.
- DBS促进了吗啡CPP的灭绝并减少了恢复.
- 200μA的ACC DBS恢复了NOR记忆和运动活动,并降低了NAc和PFC中的c-Fos表达.
结论:
- ACC DBS 显示出对吗啡使用障碍的行为和神经相关的强度依赖作用.
- 这些发现表明ACC DBS是管理吗啡使用障碍的潜在治疗策略.
- 需要进一步的研究来探索ACC DBS在SUD治疗中的临床适用性.
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