在患有自闭症的幼儿中,右向大脑结构不对称
Shujie Geng1,2, Yuan Dai3, Edmund T Rolls1,4,5
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Molecular psychiatry
|January 15, 2025
概括
幼儿自闭症谱系障碍 (ASD) 显示灰质体积异常不对称,特别是在某些大脑区域的右侧方向. 这些大脑差异与ASD症状和遗传特征相关.
科学领域:
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 了解自闭症谱系障碍 (ASD) 的神经基础及其同时发生的发育迟缓/智力障碍 (DD/ID) 需要使用大脑,行为和遗传数据进行早期调查.
- 这种全面的早期研究仍然有限.
研究的目的:
- 调查ASD (带有或没有DD/ID) 和单独DD/ID的幼儿的非典型灰质体积 (GMV) 非对称性发展.
- 探索GMV不对称模式与行为,临床测量和基因表达特征之间的关联.
主要方法:
- 利用了来自1030名8岁以下儿童的横截面sMRI数据.
- 使用发育规范模型来识别与典型对照相比GMV不对称的个体偏差.
- 分析了与行为,临床数据和转录资料的关联.
主要成果:
- 在所有自闭症儿童中都观察到一种常见的异常GMV不对称模式:在下叶和前中心环中增加了向右的横向性,在极中具有更高的个体变异性.
- 患有ASD和DD/ID的儿童表现出更严重和更广泛的GMV不对称异常,与ASD症状和口头智商相关.
- 没有DD/ID的ASD儿童在不对称性方面表现出更大的个体变化,仅与ASD症状相关.
- 只有DD/ID的儿童在不对称性方面与对照没有显著差异.
- 所有患者组的GMV横向性模式与共享和独特的基因表达特征有显著的关联.
结论:
- 患有自闭症的幼儿在特定的皮质区域呈现向右的GMV不对称性,这与自闭症症状和遗传因素有关.
- 转基因病毒不对称的严重程度和表现在具有或没有DD/ID的ASD之间有所不同.
- 这些发现突出了GMV不对称性在ASD神经发育轨迹中的作用.
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