在患有新发型1型糖尿病的儿童中解释阳性腹血清学
Lydia Ramharack1, Colin P Hawkes2,3,4, Paige Coughlin1
1Division of Gastroenterology, Hepatology, & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
在患有1型糖尿病 (T1DM) 的儿童中,使用组织转胺酶免疫球蛋白A (TTG-IgA) 和内抗体 (EMA) 进行早期查是准确的. 高水平的TTG-IgA和阳性EMA在这个人群中强烈预测CD.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 1型糖尿病 (T1DM) 经常与腹腔疾病 (CD) 相关.
- 在T1DM患者中,对CD的查实践各不相同.
- 准确的早期查对于及时诊断和管理至关重要.
研究的目的:
- 评估在新诊断为T1DM的儿童中早期乳病查的准确性.
- 确定组织转胺酶免疫球蛋白A (TTG-IgA) 和内体抗体 (EMA) 对T1DM中CD的预测值.
- 评估儿童T1DM队列中CD的发生率.
主要方法:
- 在2013年至2019年期间诊断出1,292名T1DM儿童的回顾性分析.
- 包括人体测量数据,血清学 (TTG-IgA,EMA),血液pH值,碳酸盐和血红蛋白A1c.
- 使用千平方和ROC曲线进行统计分析,以确定CD预测的最佳切断水平.
主要成果:
- 观察到CD的总发病率为3.6% (1292名儿童中有47名).
- 阳性EMA和TTG-IgA水平≥8倍以上的正常值是CD的100%预测.
- 胃肠道症状,BMI和甲状腺疾病并不是显著的预测因素,尽管注意到BMI较低和TTG-IgA较高的趋势,HgbA1c升高.
结论:
- 在T1DM患者中早期查胰腺疾病是可靠的,并促进及时诊断和治疗.
- 提升的TTG-IgA和EMA阳性是T1DM中共存CD的强有力的指标.
- 需要进一步的前性研究来完善T1DM中CD查的风险分层算法.
更多相关视频
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
