戒烟是肺癌发病和死亡率的保护因素:基于人口的前性队列研究
Wei Yin1,2, Zhuochen Lin3, Wei-Jie Gong4
1Department of Thoracic Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.
BMC cancer
|January 15, 2025
概括
戒烟,即使在60岁以后,也可以延迟肺癌的发病. 15年前戒烟的前吸烟者显著降低了肺癌和全因死亡风险.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 吸烟是肺癌的主要可改变的风险因素.
- 戒烟持续时间对LC发病时的年龄 (AAO) 和死亡率的影响尚不清楚.
- 调查戒烟对LC结果的影响对于公共卫生战略至关重要.
研究的目的:
- 调查戒烟行为与LC开始时的年龄 (AAO) 之间的关联.
- 检查戒烟对所有原因和LC特定死亡率的影响.
- 确定戒烟的最佳时间和持续时间,以减轻LC风险.
主要方法:
- 利用了来自2671名LC患者的英国生物库数据.
- 对于AAO和Cox模型的死亡结果,采用了通用线性回归.
- 数据被随机分配到发现 (n=1872) 和验证 (n=799) 集.
主要成果:
- 60岁后戒烟与男性和女性的晚期LCAAO有关.
- 超过15年的停产与男性延迟的AAO相关.
- 在60岁之前戒烟,尤其是在40岁之前,显著降低了全因和LC特定死亡风险.
- 与持续吸烟者相比,戒烟超过15年的前吸烟者显示死亡风险降低.
结论:
- 戒烟仍然有利于延迟LC的发生,即使在60岁后开始戒烟.
- 戒烟超过15年可以显著降低患上LC的风险和相关死亡率.
- 早期和持续的戒烟为减少LC发病率和死亡率提供了长期的实质性益处.
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