睡眠和昼夜节律在延迟睡眠-清醒阶段障碍:与并发性抑郁症患者和没有并发性抑郁症患者之间的表型差异
Cátia Reis1,2,3, Luísa K Pilz4,5, Teresa Paiva3,6,7
1GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.
Journal of sleep research
|January 15, 2025
概括
与没有抑郁症 (DSWPD-ND) 患者相比,患有延迟睡眠-觉醒阶段障碍和抑郁症 (DSWPD-D) 的患者在工作日睡眠时间更长,社交时差更小. 这些发现表明潜在的生物心理社会因素影响DSWPD-D.
科学领域:
- 睡眠医学 睡眠医学
- 时间生物学 时间生物学
- 精神病学是一个精神病学.
背景情况:
- 延迟睡眠-清醒阶段障碍 (DSWPD) 的特点是睡眠时间的慢性困难.
- DSWPD经常与抑郁症同时发生,这表明潜在的共同潜在机制或影响.
研究的目的:
- 为了比较DSWPD患者与并发性抑郁症 (DSWPD-D) 和没有 (DSWPD-ND) 之间的睡眠模式和昼夜节律.
- 确定潜在的表型差异,这些差异可能有助于理解DSWPD-D病因和治疗.
主要方法:
- 对162名DSWPD患者 (70名DSWPD-D,92名DSWPD-ND) 的临床记录进行了回顾性分析.
- 评估工作/假日的睡眠行为,睡眠时间,社交时差,时间型和暗光黑激素发作 (DLMO).
- 使用t测试和曼-惠特尼U测试进行统计比较;多变量Poisson回归调整为年龄和性别.
主要成果:
- 与DSWPD-ND.相比,DSWPD-D患者在工作日的睡眠时间更长 (7.63比6.20小时),睡眠开始/觉醒时间较晚,社交时差较少.
- DSWPD-D患者报告了更高的焦虑症状和药物使用,并显示了更广泛的DLMO阶段关系与睡眠/清醒时间.
- 多变量分析将DSWPD-D与增加药物使用,减少社交时差和更长的每周睡眠时间联系起来.
结论:
- 在有并发性抑郁症和没有并发性抑郁症的DSWPD之间存在显著的表型差异.
- 结果表明DSWPD-D的潜在生物心理社会保护因素,如减少社交时差和更长的睡眠时间.
- 需要进一步的研究来验证这些差异及其对DSWPD治疗的临床影响.
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