长非编码RNA作为非肌肉侵入性膀癌的预后生物标志物:系统性审查
Ahmad Z Hendri1,2, Sri Suryawati3,4, Didik S Heriyanto5,6
1Division of Urology, Department of Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Narra J
|January 16, 2025
概括
长非编码RNAs (lncRNAs) 显示为非肌肉侵入性膀癌 (NMIBC) 的生物标志物具有前途. 过度表达UCA1和UNMIBC,以及GAS5的表达不足,与较差的NMIBC结果有关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 对于非肌肉侵入性膀癌 (NMIBC) 的传统预后工具往往高估了风险.
- 需要更精确的生物标志物来预测NMIBC进展和复发.
- 在膀癌中对长非编码RNA (lncRNAs) 的现有审查没有专门关注NMIBC.
研究的目的:
- 研究 lncRNAs 在预测NMIBC生存和进展中的作用.
- 解决针对NMIBC的lncRNA生物标志物的研究缺口.
主要方法:
- 通过PubMed,Scopus和Cochrane数据库,对到2024年7月31日发表的研究进行系统审查.
- 纳入标准侧重于检查lncRNA表达和NMIBC生存结果 (例如,无疾病生存,无复发生存) 的预后研究.
- 分析了三项涉及279名NMIBC患者的研究,重点是尿癌相关的1 (UCA1),生长停止特定的5 (GAS5),以及对非肌肉侵入性膀癌 (UNMIBC) 的上调调节.
主要成果:
- 增加的UCA1表达与较差的无病存活率 (HR: 1.974) 和无进展存活率 (HR: 3.476) 显著相关.
- 减少GAS5表达与明显更差的无疾病存活率 (HR: 2.659) 和无进展存活率 (HR: 6.628) 相关.
- 较高的UNMIBC表达与较差的无复发生存率有很强的相关性 (HR: 2.362).
结论:
- lncRNAs显示出作为NMIBC预后生物标志物的潜力.
- 过度表达UCA1和UNMIBC,以及GAS5的表达不足,是NMIBC复发和进展的重要预测因素.
- 监测这些特定的lncRNA可以改善预后,并指导NMIBC患者的临床治疗决策.
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