在毛里求斯抗生素消费和耐药性的流行病学
Lovena Preeyadarshini Veerapa-Mangroo1,2, Harena Rasamoelina-Andriamanivo1,2, Mohammad Iqbal Issack1,3
1Surveillance Epidemiologique et Gestion des Alertes (SEGA) One Health network, Indian Ocean Commission, Ebene, Mauritius.
Frontiers in antibiotics
|January 16, 2025
概括
毛里求斯的抗生素消费量很高,特别是在私营部门. 抗微生物药物耐药性正在增加,对诸如 ceftriaxone 和 meropenem 等关键抗生素的敏感性显著降低.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 是一个日益增长的全球威胁.
- 了解当地的抗生素使用和耐药性模式对于有效的干预至关重要.
研究的目的:
- 确定毛里求斯抗生素消费和耐药性的模式.
- 提供数据,用于制定针对抗AMR的有针对性的策略.
主要方法:
- 从2015年至2017年,用公斤计量抗生素消耗量和定义的每日剂量 (DDD).
- 从2015年到2023年收集的抗生素耐药性数据是针对*大肠杆菌*,*克莱布塞拉*物种,*阿西内托巴克特*物种和*假球菌*.
主要成果:
- 人类的抗生素消费量 (11,000-13,000公斤) 显著超过动物消费量 (700-1,500公斤).
- 私营部门显示,对WATCH和RESERVE抗生素的消费较高.
- 观察到多种药物耐药性 (MDR) 的增加: *Acinetobacter baumannii* (58%至74%), *Pseudomonas aeruginosa* (33%至45%).
- 在关键病原体中降低对 ceftriaxone 和 meropenem 的敏感性.
结论:
- 该研究强调了毛里求斯显著的抗生素消费和AMR上升.
- 一个健康的方法对于有效的AMR制至关重要.
- 调查结果应该为毛里求斯的AMR国家行动计划提供信息.
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