对患有莱姆病的幼儿增加了多西环林的使用
Amy D Thompson1, Desiree N Neville2, Laura L Chapman3
1Division of Emergency Medicine, Nemours Children's Hospital and Sidney Kimmel Medical College of Thomas Jefferson University, Wilmington, DE, United States.
Frontiers in antibiotics
|January 16, 2025
概括
针对儿科莱姆病的多西环林治疗在2015年至2023年期间在8岁以下的儿童中显著增加. 需要进一步的研究来证实它在这个年龄组的安全性和有效性.
科学领域:
- 儿童传染病 儿童传染病
- 抗微生物药物管理委员会
- 莱姆病管理 莱姆病管理
背景情况:
- 美国儿科学会建议多西环林在儿童中使用长达3周.
- 对于儿科莱姆病的多西环林使用趋势没有得到充分的记录.
研究的目的:
- 检查诊断为莱姆病的儿童的多西环林治疗趋势.
- 为了根据患者年龄和疾病阶段对多西环林的使用进行比较.
主要方法:
- 从2015年到2023年对1,154名患有莱姆病的儿童 (1-21岁) 进行前性队列研究.
- 莱姆氏病病例由红血红斑或阳性血清学定义,分为早期局部化,早期传播或晚期.
- 后勤回归用于根据年龄和疾病阶段分析治疗趋势.
主要成果:
- 在老年儿童 (≥8岁) 和早期传播莱姆病的儿童中,多西环林的使用率更高.
- 在8岁以下的儿童中,多西环林的使用率从2015年的6.9%上升到2023年的67.9% (OR,每年1.45).
结论:
- 多西环林越来越多地被处方给患有莱姆病的幼儿.
- 前性研究对于验证多西环林在8岁以下儿童的安全性和有效性至关重要,特别是在长时间治疗期间.
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