正常和剖析的人类上升动脉的特定层的生物机械和组织学特性
Xiaoya Guo1, Han Yu2, Liang Wang3
1School of Science, Nanjing University of Posts and Telecommunications, Nanjing, 210023, China.
Heliyon
|January 16, 2025
概括
大动脉内心层中的组织硬性在患有大动脉剖析的患者中显著增加. 这种增加的硬度,加上纤维密度的变化,表明它可能是检测大动脉剖析的关键指标.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 材料科学 材料科学 材料科学
背景情况:
- 了解大动脉组织的结构性和机械性质之间的关系对于诊断大动脉疾病至关重要.
- 之前的研究没有统计性地比较正常与剖析的上升大动脉的层特异性机制和组成.
研究的目的:
- 为了比较正常和A型大动脉剖析上升大动脉的层特异性机械特性和微观结构组成.
- 根据组织特征确定大动脉剖析的潜在指标.
主要方法:
- 采集了18个上升大动脉标本 (13个剖析,5个正常).
- 获得完整的墙壁,intima-media和adventitia层样本.
- 进行了双轴拉伸测试,并应用了Fung型模型来量化刚度.
- 使用Elastin Van Gieson和Masson的三色染色量化弹性和原纤维密度.
主要成果:
- 在被剖析组中,与正常组 (纵向方向,拉伸比1.30,p=0.0068) 相比,内心介质层的刚度显著更高.
- 在其他方向或组织类型中,没有发现硬度的显著差异.
- 患病的组织通常表现出更低的弹性纤维密度和更高的原纤维密度在所有层.
结论:
- 在切割的大动脉中显著更高的内心介质组织度表明它是大动脉切割的潜在指标.
- 改变了弹性和原纤维密度,虽然在统计学上并不显著,但表明了患病的大动脉的微观结构变化.
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