分支链氨基酸与三种泌尿系统癌症的风险的关联:孟德尔的随机化研究

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Haotian Huang¹, Jiao Qin², Zhi Wen³

¹Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

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概括

增加的分支链氨基酸 (BCAA) 与增加前列腺癌风险有关. 这项研究发现BCAA与脏或膀癌之间没有关联,这表明存在特定的代谢联系.

科学领域:

代谢学代谢学代谢学
尿瘤学尿瘤学
遗传流行病学遗传流行病学

背景情况:

新出现的证据表明,分支链氨基酸 (BCAA) 代谢和泌尿系统癌症之间存在联系.
有限的研究存在于循环BCAA水平和尿道瘤发展之间的关联.

研究的目的:

研究循环分支链氨基酸 (BCAA) 与三种主要尿道癌的风险之间的因果关系:前列腺癌,脏癌和膀癌.
利用门德尔的随机化来评估与BCAA水平和癌症风险的遗传关联.

主要方法:

采用双向,双样本的孟德尔随机化分析.
全基因组关联研究 (GWAS) 的BCAA (总,白素,单素,氨酸) 和泌尿癌的数据来自英国生物银行,MRC-IEU和FinnGen.
逆方差加权 (IVW) 方法,MR-Egger回归和MR-PRESSO被用于分析,并使用了Cochran Q测试的异质性.

主要成果:

在循环中的总BCAA水平,白素,异黄素和氨酸以及前列腺癌 (PCa) 风险增加之间观察到显著的积极关联.
没有发现有统计学意义的证据支持BCAA水平与膀癌或癌风险之间的关联.

结论:

总BCAA,白氨酸,单氨酸和氨酸的循环水平升高与患前列腺癌的风险更高有关.
该研究没有发现BCAA水平与脏或膀癌的风险之间的相关性,这表明与前列腺癌存在特定联系.

关键词:

门德尔的随机化 (MR)膀癌:膀癌是一种癌症.分支链氨基酸 (BCAA) 是一种脏癌症是什么? 脏癌症是什么前列腺癌 (PCa) 是一种癌症.

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