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非洲家禽中的扩展谱β-乳糖酶:系统性审查

Akeemat O Ayinla¹, Ana L P Mateus²

¹Royal Veterinary College, London, United Kingdom.

Frontiers in antibiotics

|January 16, 2025

概括

产生扩展谱β-乳糖酶 (ESBL) 的大肠杆菌 (大肠杆菌) 在非洲家禽中很常见,构成公共卫生风险. 需要进一步的研究来了解这个问题在整个非洲大陆的全部范围.

科学领域:

兽医微生物学兽医微生物学
公共卫生公共卫生
抗微生物耐药性抗微生物耐药性

背景情况:

扩展谱β-乳糖酶 (ESBL) 生产细菌,特别是大肠杆菌 (E. coli),是人类和动物健康的重要病原体.
禽类中产生ESBL的大肠杆菌的存在是一个严重的公共卫生问题,因为它可能通过食物链和环境接触传播动物感染.

研究的目的:

系统地审查和确定ESBL产生的大肠杆菌及其相关基因在非洲的家禽种群中的流行情况.

主要方法:

在PubMed,ScienceDirect和Web of Science进行了全面的文献搜索,并补充了灰色文献.
对1582项已识别的研究进行了标题,摘要和全文等级的选.
审查中包括了33项符合条件的研究,报告了非洲家禽中产生ESBL的大肠杆菌.

主要成果:

现型ESBL表达在66.7%的纳入研究中得到证实.
在采样的家禽中,产生ESBL的大肠杆菌的殖民率差异很大,从1%到100%不等.
布拉基因是最频繁检测到的ESBL基因,在北非和西非占主导地位的特定变异.

结论:

在非洲各个地区的家禽中经常发现产生ESBL的大肠杆菌,这表明对人类健康的潜在风险很大.
目前的数据有限,这阻碍了对非洲家禽中ESBL真正的流行率和范围的全面了解.

关键词:

抗菌药物反症 (AMR) 是一种非洲非洲非洲在ESBLs中,ESBLs是最重要的.肠道细菌 (Enterobacteria) 是一种细菌.埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.抗微生物耐药性抗微生物耐药性禽类禽类禽类禽类系统性审查系统性审查

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