相关实验视频
Updated: Jun 2, 2025
08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
3.6K
通过改善前视神经元TRPV1神经元的功能来抵御运动热中风的热适应防御
Jing Li1, Ziqing Zhou2, You Wu1
1Department of Critical Care Medicine and Department of Anaesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China, 710032.
Theranostics
|January 16, 2025
概括
热适应 (HA) 通过增强前光学TRPV1神经元,防止运动热中风 (EHS). 这项研究确定了一个神经回路,并开发了一个基于外体的虹膜素输送以预防EHS.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 环境健康 环境健康
背景情况:
- 温室效应导致创纪录的热浪,增加了诸如运动热中风 (EHS) 等高热症疾病.
- 热适应 (HA) 通过调节体温 (Tb) 控制来保护EHS,但机制尚不清楚.
研究的目的:
- 阐明 HA 对 EHS 的保护作用背后的分子和神经电路机制.
- 为了研究介质前视区域 (mPOA) 神经元在HA诱导的温度调节中的作用.
主要方法:
- 已建立的EHS和HA小鼠模型.
- 使用RNA测序,成像,光遗传学和病毒追踪来研究mPOA神经元.
- 开发了一种基于外体的新策略,用于输送与HA相关的酸,一种与HA相关的酸.
主要成果:
- 确定了mPOA神经元表达过时受体潜在化物-1 (TRPV1) 作为Tb的关键调节器,在HA期间激活.
- 发现mPOATRPV1神经元抑制热生成,并通过投射到RPa和DMH促进血管扩张.
- 证明HA增强了mPOA神经元中的TRPV1表达,赋予了耐热性,而TRPV1切除则抵消了HA的益处.
结论:
- HA增强了前视TRPV1神经元,这些神经元通过mPOA-DMH/RPa电路积极抵御热应激.
- 通过外体介导向中枢神经系统输送的虹膜蛋白促进mPOATRPV1神经元功能,为EHS提供了潜在的预防策略.
相关概念视频
01:25Body Temperature
894
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
894
01:43Thermosensation
30.3K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
30.3K
01:26Thermoregulation
891
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
891
02:45Responses to Heat and Cold Stress
13.3K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.3K
01:29Decreased Body Temperature
602
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
602
01:25Increased Body Temperature
639
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
639