通过细胞外囊泡,PCBP2依赖的miRNAs分泌有助于EGFR驱动的血管生成

Hou-Fu Xia1,2, Xiao-Le Wang1, He-Jing Zhang1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.

Theranostics
|January 16, 2025
PubMed
概括

皮表皮生长因子受体 (EGFR) 的过度表达通过增加细胞外囊 (EV) 中的亲血管性微RNA (miRNA) 来增强瘤血管生成. 这一过程涉及蛋白质PCBP2,它与特定的miRNA基因结合,促进EV分泌和瘤生长.

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