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住院SGLT2i用于高血糖和心力衰竭的优缺点
Hayley Fried1, Yael Tobi Harris2,3, Rifka Schulman-Rosenbaum2
1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Medicine, Lenox Hill Hospital, Northwell Health, New York, NY 10075, USA.
Journal of the Endocrine Society
|January 16, 2025
概括
-葡萄糖共运输体2抑制剂 (SGLT2is) 对2型糖尿病 (DM2) 患者提供心血管和的好处. 在心力衰竭 (HF) 住院期间启动SGLT2抑制剂显示出希望,尽管不建议用于住院患者的高血糖症.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- -葡萄糖共运输体2抑制剂 (SGLT2is) 已被批准用于2型糖尿病 (DM2) 血糖控制.
- 在门诊环境中,SGLT2显示出显著的心血管和功能益处.
- 由于安全问题和有限的数据,目前的指导方针并不普遍支持SGLT2is用于住院高血糖管理.
研究的目的:
- 审查SGLT2抑制剂在患有DM2和心力衰竭 (HF) 的住院患者使用的益处和风险的现有文献.
- 探索在住院期间启动SGLT2抑制剂的潜在优势,特别是对于HF患者.
- 为在住院患者中使用SGLT2抑制剂的患者选择和风险减轻策略提供指导.
主要方法:
- 关于在住院患者中使用SGLT2抑制剂的当前证据的文献综述.
- 对住院患者的安全问题和疗效数据的分析.
- 综合发现,为临床实践指南提供信息.
主要成果:
- 不建议使用SGLT2抑制剂进行常规的住院高血糖管理.
- 新出现的证据表明,在心力衰竭住院期间,启动SGLT2抑制剂可能有好处.
- 谨慎的患者选择和风险减轻对于安全的住院患者启动至关重要.
结论:
- 虽然不用于住院高血糖症,但在住院治疗高血糖症期间启动SGLT2抑制剂可能会带来显著的优势.
- 需要进一步的研究和明确的指导方针来优化SGLT2抑制剂的住院使用.
- 考虑患者选择和风险管理的平衡方法至关重要.
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