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负磁共振成像不能用于省略初始前列腺活检 - 一项宏观研究

Kevin Arulraj¹, Sanjay Sharma², Chandan J Das²

¹Departments of Urology, All India Institute of Medical Sciences, New Delhi, India.

Prostate international

|January 16, 2025

概括

即使前列腺MRI呈阴性,34%的男性可能患有临床显著的前列腺癌 (csPCa). 在这些情况下,异常的数字直肠检查和PSA密度 (PSAD) 预测了csPCa,指导了活检决策.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
放射学放射学是一门学科.
在瘤学瘤学.

背景情况:

怀疑患有前列腺癌 (PCa) 的患者中,多达40%的患者有负的预镜MRI (nMRI).
在这些患者中,多达15%的人可能患有临床显著的PCa (csPCa).
在nMRI患者中预测csPCa可以帮助避免不必要的活检.

研究的目的:

确定多参数MRI (mpMRI) 对csPCa的负预测值 (NPV).
评估MRI报告模式对临床实践的影响.
通过nMRI识别男性中csPCa的预测因子.

主要方法:

一项IRB批准的两样性研究包括685名男性,他们接受了前列腺活检 (2016-2023年) 与预活检MRI.
评估机构与非机构MRI报告模式.
评估年龄,DRE,PSA,PSA密度 (PSAD) 和MRI报告用于nMRI患者的csPCa预测.

主要成果:

在62名nMRI患者中,34%的患者患有csPCa.
机构MRI显示的灵敏度 (96%) 和NPV (81%) 比非机构MRI更高.
在nMRI男性中,异常的DRE和PSAD≥0.25 ng/ml/cc预测了csPCa.

结论:

在接受nMRI的男性中,有34%的人在活检时发现有cspca.
机构MRI的NPV高于非机构MRI.
异常的DRE和PSAD≥0.25 ng/ml/cc与较高的csPCa发病率有关,尽管nMRI.

关键词:

活检是为了检查生物质.检测检测检测检测检测这就是为什么MRI是MRI.前列腺癌是什么意思前列腺癌是什么意思查检查查检查查检查

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