在没有人体免疫缺陷病毒的成年人中传播结核病和相关生存的危险因素
Wei Huang1, Zhentao Fei1, Bo Yan2
1Department of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Open forum infectious diseases
|January 16, 2025
概括
高龄,低体重指数 (BMI),免疫抑制疗法和末期病 (ESRD) 会增加传播结核病 (TB) 的风险和死亡率. 了解这些因素对于治疗结核病至关重要. 关键词:扩散性结核病,风险因素,死亡率,BMI,ESRD,免疫抑制疗法.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 传播性结核病 (TB) 在COVID-19大流行后正在全球复苏.
- 了解非艾滋病毒成年人的宿主风险因素对于结核病管理至关重要.
- 这项研究的重点是确定扩散性结核病患者的关键风险因素和结果.
研究的目的:
- 确定与传播性结核病相关的风险因素.
- 分析扩散性结核病的分站分布和死亡率.
- 为传播性结核病的临床管理和预防策略提供信息.
主要方法:
- 在上海公共卫生临床中心对1062例结核病例 (2017-2022) 的回顾性审查.
- 对扩散性肺结核 (PTB) 和肺外结核的基线特征和结果的分析.
- 用于识别风险因素和生存预测因素的物流回归和考克斯比例危险模型.
主要成果:
- 传播性结核病的死亡率最高 (19.8%在12个月内).
- 扩散性结核病的危险因素包括年龄≥45,BMI<18.5 kg/m2,免疫抑制疗法和末期病 (ESRD).
- 低BMI与所有扩散性结核病亚部位相关;与骨/关节结核病相关的年龄较大;女性患淋巴结核病,腹结核病,肠结核病的风险较高. 免疫抑制疗法和ESRD与各种TB亚站点相关. 与低BMI,免疫抑制疗法,ESRD,肺腔和脑膜干扰相关的生存率降低.
结论:
- 年龄,低BMI,免疫抑制疗法和ESRD是传播性结核病的重要危险因素.
- 这些因素也显著影响患者的生存率.
- 这些发现对于开发更好的临床管理和扩散性结核病的预防措施至关重要.
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