在晚期胃癌化疗中,神奇香颗粒的作用
Xiao-Jing Shi1, Yu Song1, Xue-Xue Liang1
1Department of Oncology, Zhangjiagang First People's Hospital, Suzhou 215600, Jiangsu Province, China.
World journal of gastrointestinal oncology
|January 16, 2025
概括
在标准化疗 (FOLFOX4和sindilizumab) 中添加Shenqi Shiyiwei颗粒可改善晚期胃癌患者的治疗反应和免疫功能. 这种联合治疗也减少了白血病,恶心和吐等副作用.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠病学 胃肠病学
背景情况:
- 晚期胃癌往往缺乏早期症状,导致晚期诊断.
- 晚期胃癌的治疗主要依赖于化疗和向治疗.
- 在中期或晚期诊断的患者中,手术往往是不可行的.
研究的目的:
- 为了评估助剂Shenqi Shiyiwei颗粒与FOLFOX4化疗和sindlizumab结合在晚期胃癌中的疗效.
- 评估这种联合治疗对免疫调节的影响.
- 为了在观察和对照组之间比较与治疗相关的毒性和副作用.
主要方法:
- 116名患有晚期胃癌的患者被随机分为两组.
- 观察组接受了FOLFOX4化疗,辛迪利祖马布和Shenqi Shiyiwei颗粒.
- 对照组接受了FOLFOX4化疗和辛迪利祖马布. 治疗周期为3周,至少2个周期.
主要成果:
- 与对照组 (36.21%) 相比,观察组的客观缓解率 (55.17%) 明显高于对照组 (36.21%).
- 在治疗后,观察组显示CD3+,CD4+和CD4+/CD8+水平增加,CD8+调节性T细胞和自然杀手细胞减少.
- 在观察组中,白血病,恶心和吐的发生率明显较低.
结论:
- 辅助性Shenqi Shiyiwei颗粒增强了FOLFOX4化疗和sindlizumab在晚期胃癌中的疗效.
- 这种组合疗法通过改变免疫细胞计数来积极调节免疫功能.
- 沈石义伟颗粒对晚期胃癌的临床治疗方案来说是一个有价值的补充.
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