相关实验视频

Updated: May 3, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

净化和转录的特征增殖细胞的Mesocestoides corti选择性地受到辐射的影响

Alicia Costábile¹, María Fernanda Domínguez², Inés Guarnaschelli³

¹Sección Bioquímica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.

Frontiers in parasitology

|January 16, 2025

概括

研究人员使用玛辐射研究了细胞干细胞,发现了其他平虫的保存机制. 这些干细胞可能是控制寄生虫虫物种的潜在药物点.

科学领域:

细胞生物学细胞生物学
寄生虫学的寄生虫学
基因组学就是基因组学.

背景情况:

平虫依赖干细胞进行组织再生,这使得它们对于生存和潜在的药物点至关重要.
虽然干细胞 (新芽细胞) 在平面体和体中得到了很好的研究,但它们在骨干细胞中的表征是有限的.

研究的目的:

通过使用玛辐射来研究Mesocestoides corti的干细胞.
为了在平虫物种中识别保存的干细胞标记物和机制.
评估 cestode 干细胞作为寄生虫疾病控制的目标的潜力.

主要方法:

用玛辐射来评估M. corti增殖细胞的放射敏感性.
对经辐射和未经辐射的骨进行了转录基因分析.
通过细胞分类分离了增殖细胞,并通过转录组进行了表征.

主要成果:

马辐射以剂量依赖的方式降低了M. corti的增殖细胞,需要比其他平虫更高的剂量.
辐射导致了参与细胞循环,DNA复制和修复的保存基因的下调.
对M. corti干细胞的转录形状显示,与平面神经细胞和S. mansoni干细胞有显著的重叠.

结论:

保存的干细胞生物学机制在各种平虫物种中可能是功能性的.
M. corti 的干细胞与其他平虫的干细胞具有相同的分子特征.
宿管干细胞代表了开发针对寄生虫平虫的新型策略的有希望的目标.

关键词:

细胞净化细胞净化这里是Cestodes的Cestodes.发芽细胞是一种发芽细胞.辐射辐射辐射的辐射.它们的扩散和扩散.干细胞标记物干细胞标记物翻译学翻译学翻译学翻译学

更多相关视频

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

相关概念视频

Frequency-dependent Selection

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.

Transduction

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...