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作为对APTO253的反应,NKG2D连接体MICA的细胞类型特定上调

Reem Alkhayer1, Viviane Ponath1, Elke Pogge von Strandmann1

  • 1Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.

Annals of translational medicine
|January 16, 2025
PubMed
概括

小分子APTO253增强了癌细胞中的自然杀手组2D体 (NKG2D-L) 表达,特别是MICA. 这种有针对性的诱导可能会改善自然杀手 (NK) 细胞治疗对各种癌症的疗效.

关键词:
在APTO253中,您可以使用APTO253 .与MHC I类聚相关的序列A诱导 (MICA诱导)自然杀手细胞介导疗法 (NK细胞介导疗法)天然杀手组2D (NKG2D) 是一个类型.

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