通过不同的诊断工具探索癌症患者的亲炎性调解剂和肉症之间的关联:叙述性综述
Juliana Aparecida Braga Cruz1, Leani Souza Maximo Pereira1, Daniel Steffens2,3
1Post-Graduation Department, Faculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Annals of translational medicine
|January 16, 2025
概括
支持炎症的细胞因子与癌症皮症有关,但目前的研究缺乏评估它们的标准化方法. 需要进一步的研究来确定细胞因子切断点及其与癌症相关的肌肉损失的具体联系.
科学领域:
- 在瘤学瘤学.
- 老年学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 标志着肌肉质量和功能丧失的萨尔科佩尼亚在癌症患者中很普遍.
- 慢性炎症和促炎性细胞因子是萨尔科佩尼亚肌肉代谢的关键驱动因素.
- 了解细胞因子的作用对于管理与癌症相关的肉症至关重要.
研究的目的:
- 评估促炎性细胞因子在癌症患者中鉴定肉类的作用.
- 调查目前的肉症评估方法与既定指导方针的一致性.
主要方法:
- 在Web of Science上对2005年以来发表的文章进行了系统的文献搜索.
- 其中的关键词包括"癌症"",肉症"和"亲炎性细胞因子*"或"互乐金*.
- 包括标准涵盖了各种类型的研究,不包括那些冗余的审查.
主要成果:
- 对10篇论文 (1138名患者) 的分析显示,在大多数肉症研究中,对肌肉强度和功能的评估不足.
- 对于用于鉴定皮症的亲炎性调解剂缺乏标准化.
- 大多数研究都集中在老年人身上,这使得与年龄相关的和与癌症相关的肉症之间的区别变得复杂.
结论:
- 未来的研究必须确定炎症调解者的切断点,并确定与肉症相关的特定细胞因子.
- 研究瘤类型特定的细胞因子表达是必不可少的.
- 区分与年龄相关的与癌症相关的因素在肉症是至关重要的.
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