四个非胰岛素抗胰岛素指数与中风后抑郁症风险之间的关联
Ping Wang1, Mengchao Wang1, Zhe Xie1
1Department of Neurology, the Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, People's Republic of China.
Clinical interventions in aging
|January 16, 2025
概括
四个非胰岛素基础的胰岛素抵抗 (IR) 指数是急性缺血性中风 (AIS) 患者中中风后抑郁症 (PSD) 的独立风险因素. 这些指标可以帮助识别患PSD风险较高的个体.
科学领域:
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
- 精神病学是一个精神病学.
背景情况:
- 胰岛素抵抗 (IR) 与急性缺血性中风 (AIS) 和抑郁症有关.
- 使用基于胰岛素的方法评估IR存在挑战.
- 非胰岛素基础的IR指数为研究提供了切实可行的替代方案.
研究的目的:
- 调查四个非胰岛素基础的IR指数与中风后抑郁症 (PSD) 之间的关联.
- 评估这些指数对AIS患者PSD的预测值.
主要方法:
- 一项前性队列研究包括638名AIS患者.
- 计算了四个非胰岛素基础的IR指数:甘油三糖 (TyG) 指数,甘油三糖-体重指数 (TyG-BMI),胰岛素抵抗代谢得分 (METS-IR) 和甘油三/高密度脂蛋白胆固醇比率 (TG/HDL-C).
- 在中风1个月后,使用17项汉密尔顿抑郁度量来评估中风后的抑郁症;用于分析的是二进制逻辑回归.
主要成果:
- 在完成随访的381名患者中,112名 (29.4%) 患有PSD.
- 在PSD组中观察到所有四个IR指数的较高水平.
- 后勤回归证实了IR指数和PSD之间的独立关联 (P < 0.001),较高的三位数显示风险增加 (P < 0.05).
- 在IR指数和PSD之间发现了线性剂量反应关系.
- 泰格指数显示与糖尿病有显著的相互作用 (P=0.014).
结论:
- 提升的TyG指数,TyG-BMI,METS-IR和TG/HDL-C是AIS中PSD的独立风险因素.
- 这些非胰岛素基础的IR指数显示了PSD的预测价值.
- 这些标志物有助于早期识别PSD高风险个体.
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