口服Akkermansia muciniphila生物仿真纳米疗法治疗性结肠炎 通过修复肠道上皮质屏障和恢复Redox平衡来进行向治疗
Qiqi Zhang1, Li Peng1,2, Qian Zhang1
1Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China.
一种新的纳米疗法模仿了Akkermansia muciniphila细菌来治疗性结肠炎 (UC). 这种疗法修复了肠道屏障,并减少了有害的反应性氧/物种 (RONS),在临床前模型中显示出更高的疗效.
科学领域:
- 纳米医学是一种纳米医学.
- 胃肠病学 胃肠病学
- 生物材料是一种生物材料.
背景情况:
- 性结肠炎 (UC) 涉及肠道屏障的破坏和过度反应性氧/物种 (RONS) 的产生.
- 目前的UC治疗面临的挑战是,在结肠病变中药物积累和保留率较低.
研究的目的:
- 开发一种性结肠炎 (UC) 的向纳米疗法,同时恢复肠道屏障并清除RONS.
- 提高药物在结肠病变部位的积累和保留,以改善UC治疗.
主要方法:
- 开发一种粘粘性益生菌模仿剂,一种带有氨酸剂的空心半孔普鲁士蓝色纳米疗法 (AM@HMPB@E).
- 利用静电相互作用和Akkermansia muciniphila膜生物粘合力,以向向炎症结肠病变提供治疗.
- 在UC模型中评估了体外和体内疗效,与sulfasalazine进行比较.
主要成果:
- AM@HMPB@E证明了对炎症结肠病变的特定结合.
- 该纳米疗法有效地清除了RONS (SOD和CAT类活动),并通过减少亡和升级紧密结节来修复肠道屏障.
- 与sulfasalazine相比,AM@HMPB@E在结肠炎部位中显示出更高的治疗疗效和保留时间.
结论:
- 开发的AM@HMPB@E纳米疗法为性结肠炎 (UC) 的向治疗提供了一个有希望的策略.
- 这种方法突显了同步纳米疗法在治疗炎症性肠道疾病方面的潜力.
- 提供了一个设计口服纳米药物的范式,增强了结肠病变向和保留.
更多相关视频
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
09:01Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
Published on: March 10, 2015
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
