微量营养素状况和感染Mycobacterium结核病的风险在印尼结核病例接触者中的结核病菌
Ayesha J Verrall1, Lisa Houghton2, Lika Apriani3,4
1Department of Pathology and Molecular Medicine, University of Otago, Wellington 6021, New Zealand.
Transactions of the Royal Society of Tropical Medicine and Hygiene
|January 16, 2025
概括
较高的费里水平,表明铁含量增加,与接触者患结核病 (TB) 感染的风险更高有关. 这表明铁管理可能是结核病预防策略的目标.
科学领域:
- 传染病流行病学 传染病流行病学
- 营养免疫学 营养免疫学
- 菌根菌感染 菌根菌感染
背景情况:
- 微量营养素缺乏与结核病 (TB) 易感性有关.
- 特定微量营养素水平与Mycobacterium tuberculosis (M.tb) 感染发展之间的关系需要进一步研究.
研究的目的:
- 探索选定的微量营养素水平与结核病例接触者中M.tb感染的发展之间的关联.
- 为了确定M.tb感染进展的潜在营养风险因素.
主要方法:
- 印度尼西亚班敦的一项队列研究追踪了430名结核病例接触者,最初通过干扰素玛释放试验 (IGRA) 对M.tb感染呈阴性.
- 基线血液样本分析了血红蛋白,维生素D,视网醇结合蛋白,C反应蛋白,α-1-酸糖蛋白,转激素受体,铁素,和.
- 总体铁状况是使用费里和转激素受体水平来计算的. 与IGRA转换 (表明M.tb感染) 的关联使用Poisson回归来评估.
主要成果:
- 在430个联系人中,115个 (27%) 显示IGRA转换.
- 对炎症进行调整后,提高费里丁度与IGRA转化风险增加显著相关 (IRR=1.17;p=0.03).
- 费里与M.tb感染风险之间的这种积极关联在多变量分析中持续存在 (IRR=1.27;p=0.002),而其他测试的微量营养素没有显著的关联.
结论:
- 增加的费里水平与患M.tb感染的风险更高有关,正如IGRA转换所示.
- 针对结核病例接触者的铁水平的干预措施,可能包括扣留铁补充剂,为结核病预防进行评估.
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