分析: 性结肠炎成年人的排他性肠道营养
Matthew K W Chu1,2,3, Alice S Day1,2,3,4, Lani Broad4
1School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Alimentary pharmacology & therapeutics
|January 16, 2025
概括
独家肠道营养 (EEN) 对性结肠炎有希望,具有良好的耐受性和低停药率. 然而,目前的证据不足以支持其作为辅助疗法的使用.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 炎症性肠道疾病 炎症性肠病
背景情况:
- 独家肠道营养 (EEN) 是克罗恩病的公认治疗方法.
- 在性结肠炎 (UC) 中EEN的疗效尚未得到充分证实.
研究的目的:
- 评估EEN在患有活跃UC的成年人中的有效性.
- 为了比较EEN治疗方案,安全性,耐受性和坚持性.
主要方法:
- 在多个数据库 (MEDLINE,Embase,Cochrane CENTRAL等) 中进行了系统的文献搜索. 在2024年7月之前.
- 包括实验和观察性研究对成年人活跃UC的EEN.
- 在PROSPERO注册的审查 (CRD42022319584).
主要成果:
- 包括10项研究,包括334名成年人.
- 在EEN和对照剂之间,没有发现UC缓解诱导的显著差异 (RR 1.15,95%CI 0.71-1.85).
- 在严重的UC中,EEN与皮质类固醇衰竭 (RR 0.76,95% CI 0.48-1.20) 或胆管切除风险 (RR 0.88,95% CI 0.51-1.51) 的比较物没有区别. 聚合停止使用率为3%.
结论:
- 在活跃的UC中,EEN耐受性良好, discontinuation率低.
- 没有足够的证据支持EEN作为UC的辅助疗法.
- 需要进一步使用标准化方法的高质量研究来确认EEN的有效性.
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