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Updated: Jun 2, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

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一个可诱导触发的Csy4分割架构,用于可编程RNA调制

Lihang Zhang1,2,3,4, Xinyuan Qiu5,6, Yuting Zhou1,3,4

  • 1School of Medicine, Westlake University, No. 18 Shilongshan Road, Xihu District, Hangzhou, Zhejiang, 310024, China.

Nucleic acids research
|January 16, 2025
PubMed
概括

我们开发了一个分裂CRISPR-Cas系统 (split-Csy4),以尽量减少基因治疗中的意外RNA分裂. 与全长的Csy4相比,这种工程系统显示了减少的脱效应,使得基因调节更安全.

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