缺铁与生育能力之间的关联
Annika Tulenheimo-Silfvast1, Lasse Ruokolainen-Pursiainen2, Niklas Simberg1
1Dextra Fertility Clinic, Helsinki, Finland.
Acta obstetricia et gynecologica Scandinavica
|January 16, 2025
概括
使用静脉注射铁性碳糖治疗不孕妇女的铁缺乏症显著改善了受孕率,活产率和流产率的降低. 对于不育患者来说,铁状况查至关重要.
科学领域:
- 生殖医学 生殖医学
- 血液学 血液学 血液学
- 临床产科和妇科 临床产科和妇科
背景情况:
- 在患有不孕症的女性中,缺铁很普遍.
- 铁缺乏症治疗对怀孕和怀孕结果的影响需要进一步研究.
研究的目的:
- 研究铁缺乏症治疗与不孕妇女怀孕和怀孕结果之间的关联.
- 为了评估静脉注射铁碳糖马尔托斯输液在改善生育能力和怀孕成功方面的有效性.
主要方法:
- 对292名患有不孕症和铁缺乏症 (s-ferritin ≤30μg/L) 的女性 (<43岁) 进行了回顾性观察队列研究.
- 数据收集于2015年至2020年期间,来自芬兰赫尔辛基的Dextra生育诊所.
- 治疗涉及静脉注射铁性碳素马尔托输液 (500毫克静脉注射). 评估结果:治疗前后的活产和流产率.
主要成果:
- 输液后的平均s-ferritin水平从16.2微克/升增加到81.5微克/升.
- 怀孕率从65%增加到77% (p<0.001).
- 生产率从26%上升到51%,而流产率从28%下降到13% (p<0.001).
- 经过调整的分析显示,铁治疗与更高的活产率 (OR=3.19) 和更低的流产率 (OR=0.32) 相关.
结论:
- 纠正缺铁会对受孕和怀孕的结果产生积极影响,包括更高的活产率和更低的流产率.
- 静脉注射铁是改善铁缺乏症妇女生育能力的有效治疗方法.
- 对于患有不孕症的患者,建议对铁状况进行查.
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